How much funding is available in total?

$3,000,000 across the whole programme. This is the total the funder has allocated, not an amount any single applicant can receive.

When is the application deadline?

Jun 15, 2028. Response date listed as Jun 15, 2028 12:00:00 AM EDT

Is matching funding required?

No. The source states that no matching funds are required. Cost sharing is false.

FederalOpenFixed dateNational Institutes of Health

INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

Awards up to $500,000 per recipient for business, city or township governments, county governments, for profit organizations other than small businesses, independent school districts, native american tribal governments (federally recognized), native american tribal organizations (other than federally recognized tribal governments), nonprofit, nonprofits having a 501(c)(3) status with the irs, other than institutions of higher education, nonprofits that do not have a 501(c)(3) status with the irs, other than institutions of higher education, other legal entity, private institutions of higher education, public agency, public and state controlled institutions of higher education, public housing authorities/indian housing authorities, small businesses, special district governments, state governments, tribal government, closing Jun 15, 2028.

Official page Sign in to trackVerified2026-09-04

BusinessCity or township governmentsCounty governmentsFor profit organizations other than small businessesIndependent school districtsNative American tribal governments (Federally recognized)Native American tribal organizations (other than Federally recognized tribal governments)NonprofitNonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationOther Legal EntityPrivate institutions of higher educationPublic AgencyPublic and State controlled institutions of higher educationPublic housing authorities/Indian housing authoritiesSmall businessesSpecial district governmentsState governmentsTribal GovernmentHealth & Human Services

In one sentence

INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed) awards up to $500,000 per recipient, open to business, city or township governments, county governments, for profit organizations other than small businesses, independent school districts, native…

Record fields

Program pool (total): $3,000,000
Total across all awards in this programme. Not an amount any single applicant can receive.
Award ceiling (per project): $500,000
Estimated total funding of $3,000,000 with an award ceiling of $500,000 per award and an expected number of 4 awards.
Award floor: Not confirmed
Typical award: Not confirmed
Deadline: Jun 15, 2028
Deadline type: Fixed date
Opens: May 12, 2026
Status: Open
Eligible entities: Business · City or township governments · County governments · For profit organizations other than small businesses · Independent school districts · Native American tribal governments (Federally recognized) · Native American tribal organizations (other than Federally recognized tribal governments) · Nonprofit · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Other Legal Entity · Private institutions of higher education · Public Agency · Public and State controlled institutions of higher education · Public housing authorities/Indian housing authorities · Small businesses · Special district governments · State governments · Tribal Government
Geography: Not stated
Matching funds: No
Disbursement: Not confirmed
Application effort: Not confirmed
Use of funds: Groundbreaking, exceptionally innovative, original, and/or unconventional research related to Down syndrome · Research on co-occurring conditions across the lifespan in Down syndrome · Development of transformative technologies related to Down syndrome
Currency: USD

How much money is available?

Two different figures govern a programme and they are not interchangeable. The programme pool is what the funder has allocated across every award it will make this cycle. The award ceiling is the most one applicant can be granted.

Program pool (total)Across all awards this cycle

$3,000,000

Award ceiling (per project)The most one applicant can receive

$500,000

Source wording: “Estimated total funding of $3,000,000 with an award ceiling of $500,000 per award and an expected number of 4 awards.”

Who can apply?

level

federal

Derived from the source that published this record

entity

Business, City or township governments, County governments, For profit organizations other than small businesses, Independent school districts, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofit, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education

+9more

, Other Legal Entity, Private institutions of higher education, Public Agency, Public and State controlled institutions of higher education, Public housing authorities/Indian housing authorities, Small businesses, Special district governments, State governments, Tribal Government

Source field: entity types

industry

Health & Human Services

Source field: industries

use

Development of transformative technologies related to Down syndrome, Groundbreaking, exceptionally innovative, original, and/or unconventional research related to Down syndrome, Research on co-occurring conditions across the lifespan in Down syndrome

Source field: use of funds

size limit

Not stated

Source field: applicant size limit

clause text

Foreign Organizations/International Collaborations: Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.

We store the structured fields above. Clause-by-clause text from the guidelines is not connected for this record.

When does it close?

Jun 15, 2028647 daysDeadline type Fixed date

Response date listed as Jun 15, 2028 12:00:00 AM EDT

What can the money be used for?

3 categorysThe source’s own spending categories, and what is not parsed.

Groundbreaking, exceptionally innovative, original, and/or unconventional research related to Down syndromeResearch on co-occurring conditions across the lifespan in Down syndromeDevelopment of transformative technologies related to Down syndrome

These categories come from the source's own classification. A line-item cost table, where the programme publishes one, lives in the guidelines and is not parsed for this record.

How hard is the application?

2 fieldsEffort, match requirement and reimbursement, as the source stated them.

Application effort: Not confirmed
Disbursement: Not confirmed
Matching funds: No
Cost sharing is false.

Common questions

6 questionsEvery answer is a stored field from this record. Questions the source did not answer are not asked.

How much can one applicant receive?: Up to $500,000 per recipient. The source states: “Estimated total funding of $3,000,000 with an award ceiling of $500,000 per award and an expected number of 4 awards.”.
How much funding is available in total?: $3,000,000 across the whole programme. This is the total the funder has allocated, not an amount any single applicant can receive.
When is the application deadline?: Jun 15, 2028. Response date listed as Jun 15, 2028 12:00:00 AM EDT
Who is eligible to apply?: Business, City or township governments, County governments, For profit organizations other than small businesses, Independent school districts, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofit, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Other Legal Entity, Private institutions of higher education, Public Agency, Public and State controlled institutions of higher education, Public housing authorities/Indian housing authorities, Small businesses, Special district governments, State governments, Tribal Government.
What can the funding be used for?: Groundbreaking, exceptionally innovative, original, and/or unconventional research related to Down syndrome, Research on co-occurring conditions across the lifespan in Down syndrome, Development of transformative technologies related to Down syndrome, as classified by the source.
Is matching funding required?: No. The source states that no matching funds are required. Cost sharing is false.

AI summary of the source text

Optional. Every core field on this record is already above, free and complete.

AI summary of the source text

Studio reads this record’s stored eligibility and materials text and breaks it into separate points, each quoting the exact words it came from. It never writes application prose, never guesses at a field the source did not state, and never estimates anyone’s chances.

Included with Studio

Provenance

Source pagegrants.gov

Retrieved2026-09-04

MethodAutomated check

First seen2026-09-01

The official page governs. If the source and this record disagree, the source is correct — programmes change their terms between our checks, so confirm every figure above before you apply.