FederalOpenFixed dateNational Institutes of Health

HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)

Award ceiling
Not stated
Closes
Feb 20, 2029
Last verified
2026-10-15

Per-recipient award not stated for city or township governments, county governments, for profit organizations other than small businesses, independent school districts, native american tribal governments (federally recognized), native american tribal organizations (other than federally recognized tribal governments), nonprofits having a 501(c)(3) status with the irs, other than institutions of higher education, nonprofits that do not have a 501(c)(3) status with the irs, other than institutions of higher education, others (see text field entitled "additional information on eligibility" for clarification), private institutions of higher education, public and state controlled institutions of higher education, public housing authorities/indian housing authorities, small businesses, special district governments, state governments, closing Feb 20, 2029.

Official pageSign in to trackVerified2026-10-15
City or township governmentsCounty governmentsFor profit organizations other than small businessesIndependent school districtsNative American tribal governments (Federally recognized)Native American tribal organizations (other than Federally recognized tribal governments)Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationOthers (see text field entitled "Additional Information on Eligibility" for clarification)Private institutions of higher educationPublic and State controlled institutions of higher educationPublic housing authorities/Indian housing authoritiesSmall businessesSpecial district governmentsState governmentsHealth & Human Services

In one sentence

HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) does not state a per-recipient award amount, open to city or township governments, county governments, for profit organizations other than small…

Record fields
Program pool (total)
$11,000,000
Total across all awards in this programme. Not an amount any single applicant can receive.
Award ceiling (per project)
Not confirmed
Award floor
Not confirmed
Typical award
Not confirmed
Deadline
Feb 20, 2029
Deadline type
Fixed date
Opens
Jun 16, 2026
Status
Open
Eligible entities
City or township governments · County governments · For profit organizations other than small businesses · Independent school districts · Native American tribal governments (Federally recognized) · Native American tribal organizations (other than Federally recognized tribal governments) · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Private institutions of higher education · Public and State controlled institutions of higher education · Public housing authorities/Indian housing authorities · Small businesses · Special district governments · State governments
Geography
Not stated
Matching funds
No
Disbursement
Not confirmed
Application effort
Not confirmed
Use of funds
lead optimization · early-stage development activities · IND-enabling studies · development of pharmacodynamic and/or target engagement biomarkers · preparation and submission of an Investigational New Drug (IND) application · Phase I clinical testing
Currency
USD

How much money is available?

Two different figures govern a programme and they are not interchangeable. The programme pool is what the funder has allocated across every award it will make this cycle. The award ceiling is the most one applicant can be granted.

Program pool (total)Across all awards this cycle
$11,000,000
Award ceiling (per project)The most one applicant can receive
Not stated

Who can apply?

level
federal
Derived from the source that published this record
entity
City or township governments, County governments, For profit organizations other than small businesses, Independent school districts, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification), Private institutions of higher education
+5more, Public and State controlled institutions of higher education, Public housing authorities/Indian housing authorities, Small businesses, Special district governments, State governments
Source field: entity types
industry
Health & Human Services
Source field: industries
use
IND-enabling studies, Phase I clinical testing, development of pharmacodynamic and/or target engagement biomarkers, early-stage development activities, lead optimization, preparation and submission of an Investigational New Drug (IND) application
Source field: use of funds
size limit

Not confirmed

Source field: applicant size limit
clause text

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to…

We store the structured fields above. Clause-by-clause text from the guidelines is not connected for this record.

When does it close?

Feb 20, 2029859 daysDeadline type Fixed date
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What can the money be used for?

6 categorysThe source’s own spending categories, and what is not parsed.
lead optimizationearly-stage development activitiesIND-enabling studiesdevelopment of pharmacodynamic and/or target engagement biomarkerspreparation and submission of an Investigational New Drug (IND) applicationPhase I clinical testing

These categories come from the source's own classification. A line-item cost table, where the programme publishes one, lives in the guidelines and is not parsed for this record.

How hard is the application?

1 fieldEffort, match requirement and reimbursement, as the source stated them.
Application effort
Not confirmed
Disbursement
Not confirmed
Matching funds
No

What comparable notices state

282 recordsStated ceilings on open records in the same industry.

Among open records stored under Health & Human Services, 282 of 886 state an award ceiling. Those that do run:

  • 25th percentile$350,000
  • Median$600,000
  • 75th percentile$1,500,000

A statistical estimate, not a prediction. It describes what a set of notices has published in this catalogue on the day you read it, and says nothing about what this programme will award. Records stating no ceiling are excluded rather than counted as zero, and the programme pool — what a funder has across every applicant — is a different column and is never mixed in.

Who has won this programme before?

63108 awardsAwards under the same assistance listing, not under this notice.

63108 federal awards on file under assistance listing 93.213, 93.233, 93.273, 93.279, 93.395, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865, 93.866, 93.867, the programme this notice is published under. These are not awards made under this notice — a listing covers every year the programme runs, and awards under an open notice do not exist yet.

Every award under this programme

Common questions

5 questionsEvery answer is a stored field from this record. Questions the source did not answer are not asked.
How much funding is available in total?
$11,000,000 across the whole programme. This is the total the funder has allocated, not an amount any single applicant can receive.
When is the application deadline?
Feb 20, 2029.
Who is eligible to apply?
City or township governments, County governments, For profit organizations other than small businesses, Independent school districts, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification), Private institutions of higher education, Public and State controlled institutions of higher education, Public housing authorities/Indian housing authorities, Small businesses, Special district governments, State governments.
What can the funding be used for?
lead optimization, early-stage development activities, IND-enabling studies, development of pharmacodynamic and/or target engagement biomarkers, preparation and submission of an Investigational New Drug (IND) application, Phase I clinical testing, as classified by the source.
Is matching funding required?
No. The source states that no matching funds are required.

AI summary of the source text

Optional. Every core field on this record is already above, free and complete.

AI summary of the source text

Studio reads this record’s stored eligibility and materials text and breaks it into separate points, each quoting the exact words it came from. It never writes application prose, never guesses at a field the source did not state, and never estimates anyone’s chances.

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What else is open

Also open from National Institutes of Health
Also open under the same assistance listings

A listing names the programme; a notice names one round of it. These are other rounds open now, not other years of this one.

Provenance
Source pagegrants.gov
Retrieved2026-10-15
MethodAutomated check
First seen2026-08-31
Assistance listings93.213, 93.233, 93.273, 93.279, 93.395, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865, 93.866, 93.867

The official page governs. If the source and this record disagree, the source is correct — programmes change their terms between our checks, so confirm every figure above before you apply.