FederalOpenFixed dateNational Institutes of Health

Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)

Award ceiling
Not stated
Closes
Nov 2, 2028
Last verified
2026-09-04

Per-recipient award not stated for business, city or township governments, county governments, for profit organizations other than small businesses, independent school districts, native american tribal governments (federally recognized), native american tribal organizations (other than federally recognized tribal governments), nonprofit, nonprofits having a 501(c)(3) status with the irs, other than institutions of higher education, nonprofits that do not have a 501(c)(3) status with the irs, other than institutions of higher education, other legal entity, private institutions of higher education, public agency, public and state controlled institutions of higher education, public housing authorities/indian housing authorities, small businesses, special district governments, state governments, tribal government, closing Nov 2, 2028.

Official pageSign in to trackVerified2026-09-04
BusinessCity or township governmentsCounty governmentsFor profit organizations other than small businessesIndependent school districtsNative American tribal governments (Federally recognized)Native American tribal organizations (other than Federally recognized tribal governments)NonprofitNonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationOther Legal EntityPrivate institutions of higher educationPublic AgencyPublic and State controlled institutions of higher educationPublic housing authorities/Indian housing authoritiesSmall businessesSpecial district governmentsState governmentsTribal GovernmentHealth & Human Services

In one sentence

Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required) does not state a per-recipient award amount, open to business, city or township governments, county governments, for profit organizations other than small businesses, independent school districts, native american…

Record fields
Program pool (total)
Not confirmed
Total across all awards in this programme. Not an amount any single applicant can receive.
Award ceiling (per project)
Not confirmed
No funding amounts stated on the page provided. Information on funding levels would typically be found in the full NOFO document.
Award floor
Not confirmed
Typical award
Not confirmed
Deadline
Nov 2, 2028
Deadline type
Fixed date
Opens
Mar 18, 2026
Status
Open
Eligible entities
Business · City or township governments · County governments · For profit organizations other than small businesses · Independent school districts · Native American tribal governments (Federally recognized) · Native American tribal organizations (other than Federally recognized tribal governments) · Nonprofit · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Other Legal Entity · Private institutions of higher education · Public Agency · Public and State controlled institutions of higher education · Public housing authorities/Indian housing authorities · Small businesses · Special district governments · State governments · Tribal Government
Geography
Not stated
Matching funds
No
Disbursement
Not confirmed
Application effort
Not confirmed
Use of funds
Develop and conduct investigator-initiated single site clinical trials · Efficacy trials · Comparative effectiveness trials · Pragmatic trials · Dissemination and implementation science clinical trials · Prevention strategy trials · Innovative trial designs such as platform trials, adaptive, and Bayesian designs
Currency
USD

How much money is available?

Two different figures govern a programme and they are not interchangeable. The programme pool is what the funder has allocated across every award it will make this cycle. The award ceiling is the most one applicant can be granted.

Program pool (total)Across all awards this cycle
Not stated
Award ceiling (per project)The most one applicant can receive
Not stated

Source wording: “No funding amounts stated on the page provided. Information on funding levels would typically be found in the full NOFO document.”

Who can apply?

level
federal
Derived from the source that published this record
entity
Business, City or township governments, County governments, For profit organizations other than small businesses, Independent school districts, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofit, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
+9more, Other Legal Entity, Private institutions of higher education, Public Agency, Public and State controlled institutions of higher education, Public housing authorities/Indian housing authorities, Small businesses, Special district governments, State governments, Tribal Government
Source field: entity types
industry
Health & Human Services
Source field: industries
use
Comparative effectiveness trials, Develop and conduct investigator-initiated single site clinical trials, Dissemination and implementation science clinical trials, Efficacy trials, Innovative trial designs such as platform trials, adaptive, and Bayesian designs, Pragmatic trials, Prevention strategy trials
Source field: use of funds
size limit

Not stated

Source field: applicant size limit
clause text

Foreign organizations and non-domestic components of U.S. organizations are eligible to apply. Foreign components are allowed. However, NIH will no longer issue awards to entities involving foreign subawards/subcontracts (effective May 1, 2025). Applications involving foreign subawards/subcontracts will be deemed noncompliant. The page references Section III of the NOFO for additional eligibility information.

We store the structured fields above. Clause-by-clause text from the guidelines is not connected for this record.

When does it close?

Nov 2, 2028786 daysDeadline type Fixed date

Listed as "Response date" on the opportunity posting

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What can the money be used for?

7 categorysThe source’s own spending categories, and what is not parsed.
Develop and conduct investigator-initiated single site clinical trialsEfficacy trialsComparative effectiveness trialsPragmatic trialsDissemination and implementation science clinical trialsPrevention strategy trialsInnovative trial designs such as platform trials, adaptive, and Bayesian designs

These categories come from the source's own classification. A line-item cost table, where the programme publishes one, lives in the guidelines and is not parsed for this record.

How hard is the application?

2 fieldsEffort, match requirement and reimbursement, as the source stated them.
Application effort
Not confirmed
Disbursement
Not confirmed
Matching funds
No
Cost sharing listed as false

What comparable notices state

333 recordsStated ceilings on open records in the same industry.

Among open records stored under Health & Human Services, 333 of 928 state an award ceiling. Those that do run:

  • 25th percentile$250,000
  • Median$500,000
  • 75th percentile$1,200,000

A statistical estimate, not a prediction. It describes what a set of notices has published in this catalogue on the day you read it, and says nothing about what this programme will award. Records stating no ceiling are excluded rather than counted as zero, and the programme pool — what a funder has across every applicant — is a different column and is never mixed in.

Who has won this programme before?

4386 awardsAwards under the same assistance listing, not under this notice.

4386 federal awards on file under assistance listing 93.233, 93.837, 93.838, 93.839, 93.840, the programme this notice is published under. These are not awards made under this notice — a listing covers every year the programme runs, and awards under an open notice do not exist yet.

Every award under this programme

Common questions

4 questionsEvery answer is a stored field from this record. Questions the source did not answer are not asked.
When is the application deadline?
Nov 2, 2028. Listed as "Response date" on the opportunity posting
Who is eligible to apply?
Business, City or township governments, County governments, For profit organizations other than small businesses, Independent school districts, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofit, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Other Legal Entity, Private institutions of higher education, Public Agency, Public and State controlled institutions of higher education, Public housing authorities/Indian housing authorities, Small businesses, Special district governments, State governments, Tribal Government.
What can the funding be used for?
Develop and conduct investigator-initiated single site clinical trials, Efficacy trials, Comparative effectiveness trials, Pragmatic trials, Dissemination and implementation science clinical trials, Prevention strategy trials, Innovative trial designs such as platform trials, adaptive, and Bayesian designs, as classified by the source.
Is matching funding required?
No. The source states that no matching funds are required. Cost sharing listed as false

AI summary of the source text

Optional. Every core field on this record is already above, free and complete.

AI summary of the source text

Studio reads this record’s stored eligibility and materials text and breaks it into separate points, each quoting the exact words it came from. It never writes application prose, never guesses at a field the source did not state, and never estimates anyone’s chances.

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What else is open

Also open under the same assistance listings

A listing names the programme; a notice names one round of it. These are other rounds open now, not other years of this one.

Provenance
Source pagegrants.gov
Retrieved2026-09-04
MethodAutomated check
First seen2026-09-01
Assistance listings93.233, 93.837, 93.838, 93.839, 93.840

The official page governs. If the source and this record disagree, the source is correct — programmes change their terms between our checks, so confirm every figure above before you apply.